Sequential assessment of LV function following reperfusion of a STEMI
Research type
Research Study
Full title
Evidence of myocardial stunning with sequential LV assessment via echocardiography following reperfusion of a STEMI.
IRAS ID
217398
Contact name
Eleanor Kusyk
Contact email
Sponsor organisation
NIHR Clinical Research Network (CRN)
Duration of Study in the UK
0 years, 10 months, 31 days
Research summary
The primary aim of this project is to assess whether left-ventricular (LV) function improves following reperfusion with percutaneous coronary intervention (PCI) post-ST elevated myocardial infarction (STEMI) via echocardiography. Evidence suggests that the myocardium undergoes a state of hibernation/stunning immediately following a myocardial infarction due to the process of ischemia and deprivation of oxygenated blood to the myocardium. Thus analysing LV function immediately post-reperfusion may not be the most accurate/interpretable data to use as the basis for diagnosis.\n Research suggests that LV function improves post re-establishment of blood flow yet the timeline for this recovery is still uncertain. With this being said the guidance for this LV evaluation differs whereby guidelines do not state a specific duration of recovery and thus time to assess LV function following a STEMI. Therefore this project aims to assess LV function immediately following reperfusion from PCI with or without stenting (as the baseline comparative value), 14 and 30 days post-hospital admission in an attempt to see if the process of myocardial stunning is evident through an improvement in LV function, in these sequential echocardiograms.\nPatients admitted at Worcester Royal Hospital, with a STEMI following a primary PCI (PPCI), would be approached about the study. Once provided with an information sheet detailing the patient involvement then have the option to choose whether or not to participate. Patients who wish to will be provided with two appointments to attend the cardiopulmonary unit for a target LV echocardiogram. \nThese two appointments will be used for the purposes of checking LV function at 14 and 30 days\nThe baseline echocardiogram will be carried out at bedside, as per routine/standard care.\nIf systolic function significantly improves at either follow-up assessment’s, as compared to baseline, this could provide evidence for implementing a timeline for LV assessment within the STEMI patient pathway.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
17/NW/0192
Date of REC Opinion
29 Mar 2017
REC opinion
Further Information Favourable Opinion