SENTRI version 1.

• Research type

  Research Study

• Full title

  Surveillance of Exhaled Nitric Oxide for Tracking Risk of Infection

• IRAS ID

  80999

• Contact name

  Jeremy Sizer

• Contact email

  jeremy.sizer@bedfordhospital.nhs.uk

• Sponsor organisation

  Bedford Hospital NHS Trust

• Research summary

  When patients are infected, the inflammatory process produces various volatile molecules and gases. These include nitric oxide, hydrogen peroxide, and carbon monoxide. We have developed a new technique to continuously monitor the concentration of these substances in a gas stream. SENTRI will use this new device, a laser spectrometer, to monitor the exhaled gas from the ventilator breathing system of patients ventilated for elective operations to establish a normal range, and patients ventilated on an intensive care unit. If the latter patients have or develop infection we expect to see a change in the investigated gas levels. The pattern of the changes may give an indication of the site and type of infection.

• REC name

  Yorkshire & The Humber - Leeds West Research Ethics Committee

• REC reference

  14/YH/0138

• Date of REC Opinion

  29 May 2014

• REC opinion

  Further Information Favourable Opinion