Sensory phenotyping of the oesophageal mucosa in GORD
Research type
Research Study
Full title
Characterisation of the sensory phenotype of the oesophageal mucosa in adults with gastro-oesophageal reflux disease
IRAS ID
257866
Contact name
Philip Woodland
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
A major determinant of perception of symptoms in gastro-oesophageal reflux disease is the mucosal afferent innervation that senses the noxious luminal contents. Response to treatment (in the majority without mucosal injury) is based on symptomatic relief. The mucosal determinants of reflux perception are therefore an important potential therapeutic target. We wish to describe the mucosal characteristics of different gastro-oesophageal disease phenotypes, elucidate the immunological and biochemical interactions that are involved in different disease states and participate in symptom generation, and assess the effect of standard medical treatment on oesophageal mucosal sensory nerves. We therefore propose to proceed with a thorough investigation that will enable us in future to better characterise patients and offer the potential for future novel treatments.
REC name
London - Queen Square Research Ethics Committee
REC reference
19/LO/1506
Date of REC Opinion
19 Dec 2019
REC opinion
Further Information Favourable Opinion