Senescence in Myocardial Infarction
Research type
Research Study
Full title
Coronary Artery Bypass Surgery after Myocardial Infarction: Identifying Clinical Outcomes by Analysing the Senescence Associated Secretory Phenotype.
IRAS ID
322782
Contact name
Omowumi Folaranmi
Contact email
Sponsor organisation
South Tees Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 3 days
Research summary
A heart attack (myocardial infarction) is when the heart doesn't get enough blood, and it's very dangerous. Even with the treatments available, the heart can get sicker over time after a heart attack. We have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse. We now want to see if checking for these aged-cell proteins in people who had a heart attack can tell us who is at the highest risk of developing heart disease.
We will take blood samples from two groups of people who had surgery. One will be people who recently had a heart attack, and the other group will be people who had the same surgery for something else. Then we will see if the people who had a heart attack have more of these proteins. We will also see if the proteins can help us predict how people recover from a heart attack.If we find that these aged-cell-proteins can predict heart disease, doctors may be able to use this information to find new ways to better diagnose heart disease and find new ways to prevent the heart disease that happens after a heart attack.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
23/PR/1222
Date of REC Opinion
5 Dec 2023
REC opinion
Further Information Favourable Opinion