Second Northwick Park Heart Study : version 1
Research type
Research Database
IRAS ID
160264
Contact name
Steve Humphries
Contact email
Research summary
Second Northwick Park Heart Study
REC name
London - Central Research Ethics Committee
REC reference
14/LO/1412
Date of REC Opinion
5 Sep 2014
REC opinion
Favourable Opinion
Data collection arrangements
The mortality data received will be linked to the anonymised database and used in statistical analysis of the
association of genetic markers, biochemical markers and lifestyle factors with coronary heart disease risk with a view
to improving the prediction of CHD risk which may in future lead to improvement of preventive measures. This data is
used by researchers within the Centre for Cardiovascular Genetics at UCL and a large number of research papers
have been published from this data. The anonymised data is also shared with other researchers at UCL for use in
consortiums which pool the data with other studies to give the large sample sizes required for work in this area. In
particular the data will be used as part of the UCLEdinburghBristol
(UCLEB) consortium of population based
prospective studies, which is a long term resource permitting powerful largescale
analyses aiming to inform public
health policy and help develop new preventive therapies.Research programme
The data held was collected between 1989 and 1998 from healthy male patients aged 5064 registered with 9 general medical practices in England and Scotland. Patients completed a questionnaire on lifestyle and medical history and blood pressure and body mass index was recorded at baseline and at 5 annual follow up visits. Blood samples were taken and biochemical measurements from the 6 visits are stored on the database. DNA was extracted and genotype results are held on the database which is updated when new genotyping is done. Information on nonfatal coronary events and diabetes was collected from the medical practices up until 2005 and is stored on the database. The only further data collection planned is the linkage of ONS mortality and cancer data as they occur in these men from the Health and Social Care Information Centre. The identifiable data on these patients is stored separately from the remainder of the database and has been through the Information Governance Toolkit Assessment process to ensure appropriate measures for data storage are in place. section 251 support has been approved for this study conditional on it receiving NRES approval.
Research database title
Second Northwick Park Heart Study
Establishment organisation
University College London
Establishment organisation address
Centre for Cardiovascular Genetics
3rd Floor, Rayne Building
5 University Street
WC1E 6JF