SCMR Registry - UK Multicentre Database

• Research type

  Research Database

• IRAS ID

  323067

• Contact name

  Alistair Young

• Contact email

  Alistair.Young@kcl.ac.uk

• Research summary

  A Multi-Center Registry of Cardiovascular Magnetic Resonance Data for Research, Education, and Quality Control Purposes.

• REC name

  East of England - Cambridge East Research Ethics Committee

• REC reference

  23/EE/0137

• Date of REC Opinion

  23 Jun 2023

• REC opinion

  Favourable Opinion

• Data collection arrangements

  Study population consists of patients with suspected or diagnosed heart disease and who have undergone one or more cardiac MRI examinations.

  Inclusion Criteria:
  - Patients who have undergone imaging investigations for the diagnosis or evaluation of structural heart disease Exclusion Criteria:
  - Patients who have opted out of data sharing

  The database will comprise of a minimum (but not absolutely limited to the following) categories of data which are already held within the contributing site NHS Trust information systems.
  - Demographic data: data and month of birth, Ethnicity (as included within the electronic patient record)
  - Anthropometric data: height and weight, BMI
  - Haemodynamic data: e.g. blood pressure and heart rate (where available)
  - Comorbidity data
  - Non-MRI Imaging Investigations - reports
  - MRI Imaging Investigations - reports and image data
  - Non-imaging Investigation data - electrocardiograms, blood test results
  - Medication histories (where available and relevant)
  Where necessary data may be supplemented by external sources using specific requests from NHS digital/ONS
  - morbidity: hospital admission, admission diagnosis, length of stay
  - mortality: date of death, cause of death

• Research programme

  Over 100,000 patients throughout UK receive cardiac MRI investigations yearly, however, most are only reviewed for immediate clinical needs (heart disease diagnosis/evaluation), and not used for cost/benefit evaluation or quality assessment. Real world experience is invaluable for evaluation of impact/efficacy; study aims to make use of anonymized retrospective data acquired routinely for clinical evaluation of patients with heart disease as part of standard clinical care, to create a UK repository, which can be joined with existing SCMR registry to enable; • Evaluation of imaging and clinical characteristics relating to outcome in different sub-groups of patients with heart disease. • Evaluation of the cost-benefit of cardiac MRI examinations in UK. • Evaluation of outcomes including death and subsequent hospitalization over many patient years. Analysis will provide the opportunity for; • Identification of sub-groups most under-represented in current practice, and drive more equitable healthcare. • Identification of sub-groups which do not require such expensive imaging procedures, thus reducing overall cost to healthcare system. • Evaluating types of imaging protocols run and for what purposes. • Evaluating relationships between imaging biomarkers and outcomes. • Developing/validating machine learning methods to derive imaging biomarkers and predict which patients would benefit most from cardiac MRI. • Quality assessment and training to improve cardiac MRI exams.

• Research database title

  A Multi-Center Registry of Cardiovascular Magnetic Resonance Data for Research, Education, and Quality Control Purposes.

• Establishment organisation

  King's College London/Guy's and St Thomas NHS Foundation Trust

• Establishment organisation address

  St Thomas' Hospital

  249 Westminster Bridge Road

  SE1 7EH