Saxenda in Obesity Services (STRIVE Study)
Research type
Research Study
Full title
EFFECTIVENESS AND COST OF INTEGRATING A PROTOCOL WITH USE OF LIRAGLUTIDE 3.0 MG INTO AN OBESITY SERVICE: (STRIVE STUDY)
IRAS ID
219773
Contact name
Melanie Davies
Contact email
Sponsor organisation
University of Leicester
Eudract number
2016-004511-12
Duration of Study in the UK
3 years, 2 months, 2 days
Research summary
Adults with obesity are at increased risk of developing associated health complications compared to patients who are of normal weight. Liraglutide 3.0mg (Saxenda) has been recently approved for the treatment of obesity, which has demonstrated its safety and effectiveness. In people with obesity, Liraglutide 3.0mg (Saxenda) has been shown to improve blood pressure and diabetes control as well as to prevent diabetes development in those with prediabetes.
However, Liraglutide 3.0mg (Saxenda) is not equally effective in all people with obesity and the high cost of the medication makes it less attractive to the health service for use routinely in obesity clinics. Previous studies have shown that approximately 14% of the people who will use the medication will be able to achieve more than 15% weight loss at one year after the treatment (“good” responders) and the vast majority of the “good” responders will achieve significant weight loss from the first months of treatment.
The aim of this study is to investigate the effectiveness and cost-effectiveness of Liraglutide 3.0mg (Saxenda) in the obesity clinic settings with a protocol for targeted use of the medication in patients who are “early” and “good” responders to the treatment. This approach is expected to minimise the side-effects and unnecessary exposure of those who will not achieve significant weight loss with Liraglutide 3.0mg (Saxenda), optimise the costs of the medications and target the patients who will benefit more from its use.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
17/EE/0208
Date of REC Opinion
26 May 2017
REC opinion
Unfavourable Opinion