SAPS
Research type
Research Study
Full title
Investigation into the pathogenic role and function of IgG Serum Autoantibodies in Complex Regional Pain Syndrome (CRPS).
IRAS ID
181615
Contact name
Andreas Goebel
Contact email
Sponsor organisation
Research, Development & Innovation Team- The Walton Centre NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, days
Research summary
Complex Regional Pain Syndrome (CRPS) is a severe chronic pain in your limb. People usually develop CRPS after a trauma, but both the pain intensity and the pain duration are in no proportion to the severity of the trauma. Unfortunately until now we do not understand what causes CRPS, and only few effective treatments exist. Patients with CRPS have special immune substances (‘autoantibodies’) in their blood. It is possible that these immune substances contribute to causing CRPS, but this has not yet been fully proven. We would now like to understand whether autoantibodies cause CRPS, and which the type of autoantibodies that are involved. Ultimately we hope that a better understanding will lead to new therapies for CRPS.
The SAPS study aims to investigate the role of autoantibodies in CRPS development and determine if we can develop effective treatments against them.
Participants must be ≥18 years old and been diagnosed with CRPS I or II for over 1 year, without other significant chronic pains. Participants must have a mean pain intensity of 6 or above on an 11 point numerical rating scale (0='no pain', 10='pain as bad as you can imagine'). Participants will have clinical evidence of hyperalgesia. Healthy Volunteers will be age ± 10 years and gender matched to the CRPS participants.
The study will involve five study visits over 1 and a half years at the Walton Centre Trial Unit where blood will be taken. Serum will be separated from the blood to be used in laboratory studies.REC name
North West - Haydock Research Ethics Committee
REC reference
15/NW/0467
Date of REC Opinion
19 Aug 2015
REC opinion
Further Information Favourable Opinion