Salivary factors affecting enamel pellicles version 1
Research type
Research Study
Full title
Salivary proteases affecting acquired enamel pellicle proteins in healthy adults
IRAS ID
143921
Contact name
Guy Carpenter
Contact email
Sponsor organisation
Kings College London
Research summary
This research study aims to collect in vivo acquired enamel pellicles from up to 10 healthy adults. Participants will have good dental health and no evidence of dental erosion. They will be fitted for a splint to be worn in the mouth for one hour. The splint will contain enamel specimens prepared from previously extracted caries-free human teeth that have been sterilised via conventional radiation and chemical techniques. Whole saliva stimulated by chewing on a piece of tasteless wax will be collected from the participants. After wearing the splints for an hour they will be removed and all further testing will be conducted in the laboratory. The in vivo enamel pellicles formed during the splint wearing will be tested for thickness, protein content, and reaction to salivary proteases.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
14/LO/0058
Date of REC Opinion
10 Feb 2014
REC opinion
Further Information Favourable Opinion