S100 & CD31 in tongue cancer
Research type
Research Study
Full title
Perineural and vascular invasion in tongue cancer: is detection improved using markers for nerves and blood vessels?
IRAS ID
152398
Contact name
Andrew W Barrett
Contact email
Sponsor organisation
Queen Victoria Hospital NHS Foundation Trust
Research summary
Microscopic invasion of nerves and blood vessels in oral cancer was an unfavourable prognostic indicator, but depended on the histopathologist sampling the tumour adequately and then identifying these features in tissue sections using routine haematoxylin and eosin (H&E) stains. There was evidence that suggested that staining the section for a marker of nerves and the cells lining blood vessels and capillaries increased the microscopic detection of perineural and vascular invasion by 52% and 12% respectively. Thus nerve and vascular invasion could be significantly under-reported. The study team were currently auditing the incidence of perineural and vascular invasion by cancers arising in sub-sites within the oral cavity and aimed to assess the degree of under-reporting, if any, in a sample of 60 cancers of the tongue.
REC name
North of Scotland Research Ethics Committee 1
REC reference
14/NS/0081
Date of REC Opinion
9 May 2014
REC opinion
Favourable Opinion