RV Markers of future Pacing Induced Ventricular Dysfunction - PILOT
Research type
Research Study
Full title
Does a measure exist in the Right Ventricle which can act as a surrogate marker for future Ventricular dysfunction when pacing – A Pilot study
IRAS ID
135613
Contact name
Stuart Tan
Contact email
Sponsor organisation
Basildon and Thurrock University Hospital
Research summary
This is a pilot study into the effects on heart function when pacing the right ventricle(RV). This study aims to enrol a population who are clinically indicated to receive a pacemaker.
When normal conduction within the heart fails, the treatment may be to implant a permanent pacemaker. Pacing involves passing a lead via a vein to the heart and using an electrical impulse to stimulate a beat.
Increasingly the available evidence suggests that long term RV pacing is associated with complications – LV dysfunction, heart failure, AF and death in some patients. What we do not see are a large proportion of all patients who receive pacemakers suffering pacing related adverse effects.
If there could be a way of identifying those patients in the group who go on to develop pacing induced cardiomyopathy at the time of initial pacing implant, this would be a very valuable clinical measure. These patients could be identified from the outset and paced with a biventricular device to avoid the pacing induced cardiomyopathy. Whilst much energy has been directed towards the LV as a focus of the clinical markers of disease, little has been published looking at RV haemodynamics.
We plan to study a cohort of patients who are clinically indicated to receive a pacemaker and study their RV in detail at the time of implantation. We will use conductance catheters and echocardiography to determine measures of pumping function. We will then follow them up for a period of six month using echocardiography and blood markers of heart dysfunction. In those patients who have a reduction in heart function we will then look for common patterns within their initial measurements.
The study centre will be the Essex Cardiothoracic Centre.
The study will be open until recruitment of 15 patients, estimated to be 6 months.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
14/EE/0167
Date of REC Opinion
4 Jul 2014
REC opinion
Further Information Favourable Opinion