ROLO The Renoprotective value of Leukodepletion in Heart Valve surgery

• Research type

  Research Study

• Full title

  The Renoprotective value of Leukodepletion in Heart Valve surgery: an external feasibility randomised controlled trial

• IRAS ID

  120825

• Contact name

  Augustine Tang

• Contact email

  Augustine.Tang@bfwhospitals.nhs.uk

• Sponsor organisation

  Blackpool Teaching Hospitals NHS Foundation Trust

• Research summary

  Having a heart operation can affect the functioning of other organs in the body and sometimes people suffer from damage to their kidneys as a result of their surgery. This is called cardiac surgery associated acute kidney injury (CSA-AKI). The risk of acute kidney injury is greater in people having heart valve operations, compared to other types of heart operation. Most people completely recover from heart surgery related acute kidney injury, but some people will experience long-term kidney disease, affecting their quality of life. Acute kidney injury can increase the length of time patients spend in hospital after their operation and therefore increase the cost of care.
  One of the reasons heart valve surgery patients suffer from acute kidney injury is because during the operation they are attached to a ‘heart-lung bypass’ machine. This machine takes over the job of pumping blood around the body whilst the heart is being operated on. The white blood cells (leukocytes) circulating in the blood then react to the materials in the heart-lung bypass machine, which ‘activates’ them and causes inflammation throughout the body. This inflammation can damage the kidneys.
  This study is looking to see if removing the ‘activated’ white blood cells from the blood (through a special filter in the heart-lung bypass machine) during surgery will reduce damage to the kidneys

• REC name

  North West - Preston Research Ethics Committee

• REC reference

  13/NW/0728

• Date of REC Opinion

  4 Nov 2013

• REC opinion

  Favourable Opinion