Role of 3D echocardiography knowledge-based reconstruction in ACHD

• Research type

  Research Study

• Full title

  Role of three-dimensional echocardiography knowledge-based reconstruction in monitoring right ventricle remodelling following Tetralogy of Fallot repair

• IRAS ID

  324811

• Contact name

  Yaso Emmanuel

• Sponsor organisation

  Guy's & St Thomas' NHS Foundation Trust R&D Department

• Duration of Study in the UK

  1 years, 6 months, 30 days

• Research summary

  Adult patients with congenital heart disease (ACHD) spent much of their life in and out of hospital. In most cases, cardiac magnetic resonance imaging (CMR) is necessary for a good assessment of the right side of the heart, which implies entering a narrow tunnel and staying still for a long period of time. This is often stressful and not well tolerated by patients.
  The purpose of this research is to test a three-dimensional (3D) knowledge-based cardiac ultrasound technique that uses standard two-dimensional (2D) images of the right heart and compare it to CMR to help monitor ACHD patients with a repaired condition called Tetralogy of Fallot (ToF). Cardiac ultrasound technique in general is known to be safe, well tolerated by all patients and is included in hospital follow-up visits.
  The goal is to initially test the 3D knowledge-based cardiac ultrasound technique using a research only echocardiogram to assess the size and function of the right heart in a group of 22 healthy volunteer colleagues within 2 visits separated for a maximum of 14 days.
  We will then select a specific group of 50 adult patients with congenital heart disease, which has already been referred for CMR, and assess with a research only echocardiogram how the 3D knowledge-based ultrasound technique and all the traditional measurements compare to the CMR results. This will be performed during their standard of care CMR visit. We will keep studying the same group of patients for 1 year to understand how these measurements could be used for routine long-term follow-up. In total there will be also to 2 visits for this group separated for a maximum of 1 year.
  This research may help ACHD patients to have more stress-free imaging tests that can assess the size and function of their right heart as precisely as CMR.

• REC name

  London - Stanmore Research Ethics Committee

• REC reference

  24/PR/0045

• Date of REC Opinion

  30 Jan 2024

• REC opinion

  Further Information Favourable Opinion