Risk of angiosarcoma after radiotherapy for breast cancer in Wales.
Research type
Research Study
Full title
Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. A South West Wales experience.
IRAS ID
253520
Contact name
Maurizio Brotto
Contact email
Sponsor organisation
Cellular Pathology
Duration of Study in the UK
0 years, 6 months, 8 days
Research summary
The investigation is going to be a retrospective study of women with localised breast carcinoma who were diagnosed between 1991-2017 in South West Wales. Numerous case reports have reported the occurrence of soft tissue Sarcoma in the vicinity of anatomic fields previously irradiated for breast carcinoma. The aim of this retrospective study is to assess the risk of soft tissue Sarcoma ( Angiosarcoma) in relation to radiotherapy, histological type and to describe the temporal pattern of radiation-associated risk since the initial radiotherapy.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
19/WM/0028
Date of REC Opinion
28 Jan 2019
REC opinion
Favourable Opinion