Rheolytic Thrombectomy For Adult Intraventricular Haemorrhage (rtIVH)
Research type
Research Study
Full title
A Pilot Cohort Study of Rheolytic Thrombectomy with AngioJet Catheters For the Treatment of Intraventricular Haemorrhage in Adults
IRAS ID
145044
Contact name
Peter J Kirkpatrick
Contact email
Sponsor organisation
Research and Development Dept, Cambridge University Hospitals NHS Foundation Trust
Research summary
Intraventricular haemorrhage (IVH) – bleeding into fluid spaces within the brain – is associated with a high risk of death and l disability. IVH leads to an increase brain pressure, inflammation and swelling. The ideal treatment for IVH would relieve pressure and remove the blood clot. Currently, no such treatment exist.
Drains inserted as temporising measures frequently block and require further operations increasing the risk of infection. Experimental treatments such as local administration of blood thinning medications and surgical removal of clot are unsuccessful and risky.
We plan to evaluate a novel instrument that employs a pressurised microjet of water to mechanically disrupt blood clots and sucks the debris. This technique has been highly successful in reopening blocked arteries in the heart. In the context of IVH, this should allow rapid removal of blood from the ventricles while causing minimal trauma to the brain. Clearing the blood early will prevent the build-up of pressure and inflammation, and improve the chances of patients making a good recovery.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
14/EE/1024
Date of REC Opinion
1 Sep 2014
REC opinion
Further Information Favourable Opinion