REVOLUTION Surgery
Research type
Research Study
Full title
Routine Evaluation of People Living with Cancer - Surgery
IRAS ID
311387
Contact name
Richard Skipworth
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Some people with cancer suffer from muscle wasting, lose weight and feel tired. This process, termed cachexia, is a significant problem and can lead to a reduction in both quality and quantity of life.
Cachexia is caused by interactions between the tumour and the patient. Historically, it was considered to be a purely end-stage phenomenon of advanced cancer, however, it is now known that early signs of cachexia can even influence the outcomes of patients with potentially curative pathology, including those planned for a surgical resection.
This study aims to collect information, from patients who are at risk of cachexia, about body composition, physical activity, quality of life and the body’s immune response to cancer. Previously these measures have been most frequently studied in isolation, or at one single time-point, and are therefore likely to give an incomplete picture. A more holistic characterisation of surgical patients at risk of cancer cachexia, across their treatments, is currently lacking.
Participants with cancer will be recruited to the study from surgical services in the UK. A small number of 'control' patients without cancer, who are undergoing surgery for a benign condition, will also be recruited for comparison. Those recruited will have their height and weight measured, answer questionnaires about quality of life, undergo assessment of their physical function and levels of activity, have blood taken to analyse markers of inflammation and have their body composition measured by a variety of methods. A subgroup of patients will also undergo an additional MRI scan of their abdomen and thighs. At the time of their operation, they will also have small biopsies of muscle, fat, tumour and urine taken for biochemical analysis. Patients with cancer, will be asked to return for three follow up appointments during the year after their operation where these assessments will be repeated.
REC name
West of Scotland REC 4
REC reference
22/WS/0174
Date of REC Opinion
25 Apr 2023
REC opinion
Further Information Favourable Opinion