REVIVAL Trial
Research type
Research Study
Full title
Ross for Valve replacement in Adults(REVIVAL) trial
IRAS ID
268532
Contact name
Serban Stoica
Contact email
Sponsor organisation
Population Health Research Institute
Clinicaltrials.gov Identifier
Duration of Study in the UK
10 years, 0 months, 11 days
Research summary
Heart valves help control blood flow through the heart and, if diseased, may need to be replaced. After having a heart valve replaced, patients have a higher risk of death than people who have not had a valve replaced. In young adult patients, replacing the aortic heart valve with a mechanical valve halves their life-span compared to other people their age. Mechanical valves tend to form blood clots so they need long-term blood thinners that increase risk of bleeding and lower quality of life. Animal tissue valves reduce clotting and bleeding risks but wear out sooner and shorten patient life-span. An operation, called the Ross procedure, replaces a patient’s diseased aortic valve with his/her own pulmonary valve and uses a donor valve in the pulmonary position which receives less stress than the aortic valve. The Ross procedure aims to improve valve durability with less clotting, avoiding use of blood thinners. REVIVAL is a research study investigating the efficacy and safety of the Ross procedure compared to conventional valve replacement. Specifically we are interested in learning the number of patients who survive without a life-threatening valve related complication, long term postoperatively.
REC name
South West - Central Bristol Research Ethics Committee
REC reference
19/SW/0166
Date of REC Opinion
24 Sep 2019
REC opinion
Further Information Favourable Opinion