RESULT Hip Version 1
Research type
Research Study
Full title
The impact of REStrictive versUs Liberal Transfusion strategy on cardiac injury and death in patients undergoing surgery for Hip Fracture (RESULT-Hip)
IRAS ID
299977
Contact name
Michael Gillies
Contact email
Sponsor organisation
University of Edinburgh
ISRCTN Number
ISRCTN28818784
Duration of Study in the UK
3 years, 6 months, 1 days
Research summary
Do patients with hip fracture have better clinical outcomes when a more liberal transfusion practice is used to treat anaemia ?
Hip fracture is the most common serious injury in older people. More than 95% of patients have surgery. This surgery is often high-risk as patients may be frail and have other health problems including heart disease and anaemia (a low blood count). Patients may be in hospital for a long time and need rehabilitation. Up to 35% of surviving patients do not return to their orginal residence and have a high rate of increased dependency.
Research suggests that 30-40% of these patients have a blood transfusion around the time of operation. However doctors are uncertain about what level of anaemia transfusions should be given at. Many current guidelines recommend transfusion at a lower level , but there is research which suggests that this level is too low particularly if the patient has a history of heart disease. In these patients, transfusion at a higher level may be better to prevent complications.
Our UK-wide study is funded by the National Institute of Health Research. We will ask older (60 years or older) people with a hip fracture and anaemia to be randomly assigned to either receive blood transfusions at a lower blood count , in line with current guidelines, or a higher level, for the duration of their hospital stay, or 30 days, whichever is soonest.
Patients will have their blood count checked before and after any blood transfusions and will have additional blood tests (Troponin) and heart tracings (electrocardiographs , (ECG)) to check their heart.
At 30 days we will measure how often post-operative heart attacks and other complications occur, how long patients stay in hospital and mortality rate. At 30 and 120 days we will measure quality of life (assessed by questionnaire).
The study will last for 4 years but each patient will only be active in the study for 120 days. The study results will help doctors looking after people with hip fracture decide when is the best time to give blood transfusions.REC name
Scotland A: Adults with Incapacity only
REC reference
22/SS/0001
Date of REC Opinion
17 Mar 2022
REC opinion
Further Information Favourable Opinion