RESPIRE-I
Research type
Research Study
Full title
Relating Environment-use Scenarios in Pregnancy/Infanthood and Resulting airborne material Exposures to child health outcomes (RESPIRE-I)
IRAS ID
329974
Contact name
Edward Johnstone
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
2 years, 7 months, 31 days
Research summary
Introduction
Exposure to air pollution is known to have detrimental effects on human health, particularly to vulnerable groups such as children. The public are increasingly spending more time indoors, yet little is known regarding how these exposures may influence health long term. Respire-I is a prospective observational cohort study that will monitor the external and ambient exposure of pregnant women to air pollution. This NERC funded study aims to examine the impact of maternal pollution exposure on pregnancy outcomes and the potential mechanisms by which damage may occur.
Location
The study will be run at sites across the UK including Liverpool, London, Swansea, Belfast, Edinburgh and Manchester, led by the University of Manchester.
Eligibility
Pregnant women, who live and plan to continue to live in the same home for at least a year will be recruited following informed consent.
Research activities
Recruitment will be conducted at booking appointment (until ~Feb 2025), the end of the study will be after 9 months post-partum of the last recruited participant (~Aug 2026). Participants will complete a sociodemographic questionnaire at recruitment (~20 mins) as well as three ~5-minute questionnaires towards the end of pregnancy. A location diary (~3 min/day) will also be completed during the time of indoor pollution monitoring (two weeks minimum). Demographic and clinical outcome data will be collected at routine clinical visits. Participants will attend a non-routine clinical visit at 6-9 months post-partum with their infant. Biological samples (blood, nasal swabs and hair) will be collected at each clinical visit. Umbilical cord blood will be collected at delivery.
Outcomes
These data will investigate the potential impact of maternal exposure to pollution upon pregnancy outcomes. The influence of sociodemographic on these associations will be considered as well as using biological samples to assess the mechanism underpinning these effects.REC name
North West - Preston Research Ethics Committee
REC reference
24/NW/0011
Date of REC Opinion
31 Jan 2024
REC opinion
Unfavourable Opinion