Respiratory Endpoints for Tobacco Harm Substantiation

• Research type

  Research Study

• Full title

  APPRAISAL OF SENSITIVE RESPIRATORY ENDPOINTS FOR EFFICIENT SUBSTANTIATION OF TOBACCO HARM

• IRAS ID

  322282

• Contact name

  Pankaj Sharma

• Contact email

  Pankaj.Sharma@rhul.ac.uk

• Sponsor organisation

  Eclat

• Duration of Study in the UK

  1 years, 6 months, 0 days

• Research summary

  The primary objective of this study is to assess whether quantitative analyses of lung microstructure as obtained by HRCT (High Resolution Computed Tomography) permit a discrimination between current, former and never smokers and to verify the repeatability of such measurements. Confirmation of good reproducibility of lung HRCT measurements would give greater confidence in the strength of this assessment for regulatory research applications on combustion-free tobacco products (e.g. e-cigarettes, heated tobacco products, oral tobacco/nicotine products), smoking cessation drugs and respiratory therapies.

• REC name

  London - Camden & Kings Cross Research Ethics Committee

• REC reference

  22/LO/0909

• Date of REC Opinion

  22 Dec 2022

• REC opinion

  Favourable Opinion