Research into Altered Lymphocyte Function (ALF) in Health and Disease
Research type
Research Study
Full title
Research into Altered Lymphocyte Function in Health and Disease (ALF Research Study)
IRAS ID
220302
Contact name
Maike de la Roche
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
Duration of Study in the UK
5 years, 11 months, 31 days
Research summary
T lymphocytes are white blood cells that are crucial for our body’s defence against infection and cancer due to their ability to eliminate infected and tumour cells and establish long-lived “memory” cells that protect against re-challenge with the same pathogen or tumour. Patients with compromised function of T lymphocytes thus have a worse immune response and can suffer from higher susceptibility to infection and tumour development.
In our research, we will use samples of blood, surplus tissue removed during future planned surgery, and archived samples removed in the past. We will characterize the immune cells from patients with altered lymphocyte function and healthy controls phenotypically and functionally. This will help us to understand how immune function is changed in patients and will give new insights into how lymphocyte function is regulated.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
17/YH/0304
Date of REC Opinion
3 Oct 2017
REC opinion
Further Information Favourable Opinion