Renal functional reserve and risk of acute kidney injury
Research type
Research Study
Full title
Preoperative renal functional reserve to predict risk of acute kidney injury after cardiac surgery
IRAS ID
271591
Contact name
Marlies Ostermann
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Foundation Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 1 months, 0 days
Research summary
Patients undergoing cardiac surgery have a high risk of acute kidney injury (AKI), and patients who develop AKI after cardiac surgery have an increased risk of dying or developing chronic kidney disease and becoming dialysis dependent.
At present, there are limited ways of determining the individual risk of AKI in patients scheduled for cardiac surgery. We believe that patients with reduced kidney function reserve have a higher risk of kidney disease during surgery. A preliminary small study in Vicenza, Italy showed that it was possible to measure kidney function reserve by giving patients a high protein meal and measuring kidney function before and after. In this study, patients who had limited kidney reserve had a higher risk of developing acute kidney injury after surgery.We would like to repeat this study to find out whether the assessment of kidney function reserve after a protein drink helps identifying those patients who are at highest risk of acute kidney injury and chronic kidney disease after cardiac surgery. If confirmed, high risk patients can be recognised earlier and hopefully acute kidney injury can be prevented.
REC name
London - Westminster Research Ethics Committee
REC reference
19/LO/1828
Date of REC Opinion
15 Jan 2020
REC opinion
Further Information Favourable Opinion