Renal Dysfunction in Acute Stroke
Research type
Research Study
Full title
Does Renal Dysfunction in Acute Stroke influence Treatments and Outcomes?
IRAS ID
174315
Contact name
Charles Ferro
Contact email
Sponsor organisation
University Hospitals Birmingham NHS Trust, Research and Development Office
Duration of Study in the UK
2 years, 5 months, 30 days
Research summary
Stroke is the second most common cause of death worldwide, after ischaemic heart disease. Chronic kidney disease (CKD) is becoming more common with increases in chronic conditions such as diabetes and our ageing population- these are known to cause CKD. CKD carries an increased risk of heart disease and is thought to increase the risk of stroke. However until now, research has mainly focussed on the relationship between heart and kidney disease, not stroke and kidney disease.
Acute renal failure, now termed acute kidney injury (AKI) is more common in CKD and is also on the rise. CKD patients, especially those who are on dialysis, do less well after stroke and have a higher chance of disability and death. Patients with AKI also do poorly but currently we don't know much about stroke patients who develop AKI. To date, there is no information on patients with stroke and kidney dysfunction in the United Kingdom.
In the past, research in patients with kidney disease has been very challenging for several reasons, including exclusion from large clinical trials due to multiple health problems. There is now a huge amount of data stored in electronic health records which offers huge potential for research in kidney patients.
This epidemiological study will determine how well patients with acute stroke and kidney dysfunction (both acute and chronic) do in comparison to stroke patients with no kidney dysfunction. Doctors need to understand the level of risk, disability and mortality in these patients to drive developments in care, including prompt recognition and treatment. Routinely collected data held in separate databases will be linked to provide a very rich dataset, allowing us to look at treatments and outcomes along the whole stroke care pathway in the NHS.
REC name
East of England - Essex Research Ethics Committee
REC reference
16/EE/0166
Date of REC Opinion
23 May 2016
REC opinion
Further Information Favourable Opinion