Regulation of chemokine and cytokine receptors in lymphocytes
Research type
Research Study
Full title
Regulation of chemokine and cytokine receptors in lymphocytes
IRAS ID
158965
Contact name
Niall Dillon
Contact email
Sponsor organisation
MRC Clinical Scieces Centre
Research summary
The immune response to pathogens depends on B lymphocytes entering sites of infection and homing to secondary lymphoid organs from the blood stream. Following pathogen encounter, the lymphocytes need to proliferate to resolve the infection. The homing processes are regulated by the action of chemical signalling molecules, the chemokines, through modulation of membrane/cytoskeletal proteins that control cell adhesion and cellular shape. The correct timing of cell proliferation is regulated by the synthesis and destruction of cell cycle regulators. The research will study gene regulation, cell migration and cell cycle control to investigate how cellular homing and cell proliferation are regulated in B lymphocytes.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
14/WM/1035
Date of REC Opinion
30 Jun 2014
REC opinion
Favourable Opinion