Regenerative Endodontic Technique for management of immature teeth V1
Research type
Research Study
Full title
Regenerative Endodontic Technique for the management of non vital immature permanent teeth in children. A study of a new treatment paradigm.
IRAS ID
108283
Contact name
Hani Abudiak
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
0 years, 11 months, 1 days
Research summary
One of the consequences of suffering trauma to the front teeth at a young age is that the blood supply to the tooth is disrupted. If the blood supply to the teeth is disrupted before the root development is completed, the child will be left with an immature root. These teeth then require root canal treatment (RCT), which is extremely complicated for immature teeth. In addition these roots are very weak. It is estimated that some half of teeth treated in this traditional RCT technique will fracture and will be lost in the first 5 years following treatment despite the conventional treatment method. A new treatment idea has recently been proposed that aims to stimulate the stem cells located near the end of the root in the bone. This technique aims at initiating new pulp formation that would then restart the root development process and the immature root can grow into a stronger root that can be retained for life. We are proposing to use a technique (Regenerative Endodontic Technique (RET)) that will aim to create these conditions for regeneration, by using a combination of two antibiotics and then creating a blood clot inside the root canal to act as a scaffold for the stem cell to proliferate. This would allow the pulp to reform. We have done some initial work in developing this intervention and propose to do a pilot study that would help us design the correct methods for carrying out a larger clinical trial with 5 other centres around the country. This intervention promises to be a new paradigm, and would revolutionise the treatment in children who suffer trauma to the front teeth. It would also save money for the NHS in the short term and over the life time of the patient.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
12/YH/0488
Date of REC Opinion
3 Dec 2012
REC opinion
Further Information Favourable Opinion