Regenerative cellular therapies, physiology, pathology and development
Research type
Research Study
Full title
A study utilising tissue from deceased organ donors to investigate regenerative cellular therapies and related physiological and developmental processes
IRAS ID
171949
Contact name
Kourosh Saeb-Parsy
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
4 years, 11 months, 28 days
Research summary
The purpose of this study is to use tissue from deceased human organ donors to address questions that are of fundamental importance for the development of regenerative cellular therapies and for better understanding of organ physiology, pathology and embryonic development. The proposed study utilises an existing multidisciplinary collaboration between leading researchers in Cambridge and beyond to maximise the scientifically and clinically valuable data, and ultimately patient benefit, that can be generated from the donated tissue. Following obtaining informed consent from the donor family, samples will be collected from tissues that have not been used for transplantation. Cells and tissue will be used to: 1) Investigate biological properties of stem cells and to develop stem cell-derived cellular therapies; 2) Study the immune response to adult cells, stem cell-derived cellular therapies and to develop new anti-rejection therapeutic approaches; 3) Study cellular and organ function and physiology; and 4) Study embryonic development of organs.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
15/EE/0152
Date of REC Opinion
13 May 2015
REC opinion
Further Information Favourable Opinion