REFRESHED Version 1.0
Research type
Research Study
Full title
REstoring FavouRablE Sleep to HElp patients with Diabetes (REFRESHED) study
IRAS ID
141361
Contact name
Martin Rutter
Contact email
Sponsor organisation
Central Manchester University Hospitals NHS Foundation Trust
Research summary
Current drug therapy for patients with type 2 diabetes fails to control sugar levels in most patients. It has many possible side-effects and due to spiralling costs and increasing patient numbers, it may not be affordable in the long-term. New treatments for diabetes are urgently needed for this common condition.
Disorders of sleep can cause problems for patients with diabetes. For example, two nights of sleep disruption can increase glucose levels, increase appetite and the intake of high-calorie foods.
We plan to study patients with type 2 diabetes attending Manchester Royal Infirmary and we will measure what proportion of these people have problems with sleep. We will assess how sleep disturbance is related to glucose levels. Interviews with patients and members of staff will assess the potential causes of sleep disturbance and will help us to design a new treatment for disturbed sleep that is acceptable to patients. This therapy focussed on improving sleep may be more acceptable to patients than treatments involving diet or exercise. There have been no clinical trials of sleep-focussed treatment in patients with diabetes.
This project will provide pilot data that will help us to obtain a major grant (application mid-2015) that will allow us to assess how well the new treatment works by performing a large clinical trial. This new treatment is expected to improve general health and well-being, obesity and glucose control and reduce the risk of diabetes complications. If delivered across the NHS, there could be important health benefits, reduced medication costs, reduced sick days and improved productivity.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
13/NW/0837
Date of REC Opinion
16 Jan 2014
REC opinion
Further Information Favourable Opinion