REACT Shock RCT
Research type
Research Study
Full title
Individualised Blood Pressure Targets versus Standard Care among Critically Ill patients with Shock - A Multicentre Randomised Controlled Trial
IRAS ID
328765
Contact name
Marlies Ostermann
Contact email
Sponsor organisation
The University of Newcastle
Duration of Study in the UK
5 years, 1 months, 31 days
Research summary
During critical illness, patients often have a low blood pressure. This increases their risk of acute kidney failure, also known as acute kidney injury (AKI). Existing guidelines recommend to keep the average blood pressure at 65mmHg. However, there is increasing evidence that some patients need a higher blood pressure target and others are safe with a lower blood pressure, depending on their blood pressure before they became ill.
In this trial, we plan to randomise critically ill patients with shock to either a blood pressure target similar to their pre-existing blood pressure or standard care. The aim is to find out whether aiming for personalised blood pressure targets increases the chances of surviving and prevents organ failure, including kidney failure. We will assess organ function using routine tests and will also measure urine and blood tests of early impairment of organ function.
REC name
London - South East Research Ethics Committee
REC reference
24/LO/0035
Date of REC Opinion
12 Jan 2024
REC opinion
Favourable Opinion