Re-evaluation of carotid artery stenosis measurement using ultrasound.
Research type
Research Study
Full title
Re-evaluation of carotid artery stenosis measurement using ultrasound. A comparison of direct stenosis measurement using B-Mode Ultrasound Doppler imaging and Doppler velocity measurements.
IRAS ID
165575
Contact name
Elaine Gardiner
Contact email
Sponsor organisation
Glasgow Caledonian University
Duration of Study in the UK
0 years, 3 months, 0 days
Research summary
The study will be using ultrasound to scan patients' carotid arteries to evaluate the current recommendations for grading stenosis which have recently come under criticism (Bryant et al, 2013). Specifically, it will compare direct visualisation measurements of lumen reduction in the internal carotid artery using B-mode ultrasound imaging with the three velocity measurements that are primarily used to grade stenosis (peak systolic velocity, peak systolic velocity ratio and the St. Mary's Ratio).
Furthermore, current Doppler ultrasound methods rely on the identification of maximum velocities i.e. PSV, despite the fact that large errors exist due to spectral broadening (Hoskins, 2011). With this in mind, mean velocities will also be calculated and compared as a possible alternative for the assessment of percentage stenosis.Bryant, C.E., Pugh, N.D., Coleman, D.P., Morris, R.J., Williams, P.T., Humphries, K.N. 2013, "Comparison of Doppler ultrasound velocity parameters in the determination of internal carotid artery stenosis", Ultrasound, Vol.21, no.3, pp.124-131.
Hoskins, P.R. 2011, “Estimation of blood velocity, volumetric flow and wall shear rate using Doppler ultrasound”, Ultrasound, Vol.19, pp.120 – 129.
REC name
London - Harrow Research Ethics Committee
REC reference
15/LO/0226
Date of REC Opinion
6 Mar 2015
REC opinion
Further Information Favourable Opinion