RCT: Makoplasty vs Navigated Oxford Unicondylar Knee Arthroplasty
Research type
Research Study
Full title
A prospective randomised control trial of Mako medial unicondylar knee arthroplasty versus jig-based Oxford unicompartmental knee arthroplasty with navigation control \n
IRAS ID
220437
Contact name
Fares Haddad
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Partial knee replacements (unicompartmental knee arthroplasty) involve removing parts of the knee joint that have become worn out and arthritic and replacing these with artificial implants. The positioning and alignment of these artificial implants is important because they influence clinical function and implant survival. Advances in surgical technology have lead to the development of computer software and robotic machines to improve implant positioning and alignment in partial knee replacements.\n\nThe Mako robotic machine uses x-rays and CT scan of the patient’s knee joint to calculate the amount of bone resection required and desired implant position. A robotic arm then guides the surgeon during surgery to ensure that only the specified amount of bone is resected and implants are positioned correctly. Navigation control uses computer software to recreate three-dimensional models of the patient’s anatomy and then uses anatomical landmarks in surgery to guide optimal implant positioning. \n\nThe objective of this study is to compare patient recovery and accuracy of implant positioning in patients undergoing partial knee replacements using the Mako robot versus computer navigation. \n\nThe study will include 140 patients with arthritis affecting the inner (medial) compartment of the knee joint undergoing partial knee replacement at University College London Hospital. Following informed consent, patients will be randomised into one of the two treatment groups and undergo partial knee replacement using either the Mako robot (Investigation group) or computer navigation (control group). All patients will receive the same rehabilitation programme following surgery. Clinical progress will be recorded at regular intervals for two years after surgery. Accuracy of implant positioning will be assessed using Computerised Tomography (CT) scan after surgery. \n\nThis study will enable us to determine which of the two surgical techniques in partial knee replacements enables faster rehabilitation, improved accuracy of implant positioning, and reduced complications.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
17/LO/0955
Date of REC Opinion
17 Jul 2017
REC opinion
Further Information Favourable Opinion