Raised ICP after ICH
Research type
Research Study
Full title
Raised intracranial pressure following intracerebral haemorrhage: association with survival and physiological variables
IRAS ID
264416
Contact name
Adrian Parry-Jones
Contact email
Sponsor organisation
University of Manchester
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
Why: Spontaneous intracerebral haemorrhage (ICH) accounts for 1 in 5 of all strokes. Caused by bleeding into brain tissue, it carries a high risk of death or disability. The brain sits tightly inside the skull, so any increase in pressure on the brain structure, known as raised intracranial pressure (ICP), resulting from high blood pressure, the blood clot itself or swelling of brain tissue after the bleed, may cause a worsening of stroke-symptoms. Treatments, which aim to reduce pressure in the brain after ICH, have been a target for stroke physicians but there is currently no evidence that these measures improve outcome for patients.
What: This project will explore existing clinical data to determine if raised ICP increases the risk of death. From the data, we will compare measurements of blood pressure recording from time of admission and from the first 72 hours of presentation with measurements of ICP, to assess if lowering blood pressure has any impact on ICP and recovery.
Who: The project will analyse patients within an existing dataset of 1500 records of patient admitted to Salford Royal NHS Foundation Trust (SRFT) following ICH, some of whom will have been treated in intensive care for the first 72 hours of their stay and had ICP measured.
Where: Data collection will be conducted at SRFT and all personal information will then be removed from the dataset making it anonymised. Analysis will be performed at the Universities of Manchester and Leicester.
How: The project will take approximately 1 year to complete from 1st May, 2019
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
19/NW/0695
Date of REC Opinion
19 Nov 2019
REC opinion
Favourable Opinion