RADAR ICU
Research type
Research Study
Full title
Role of Active Deresuscitation After Resuscitation (RADAR) in Intensive Care Unit Patients
IRAS ID
111973
Contact name
Jon Silversides
Contact email
Sponsor organisation
Belfast Health and Social Care Trust
Research summary
Critically ill patients admitted to an intensive care unit (ICU) frequently receive large volumes of intravenous fluids to correct low blood flow states resulting from life-threatening processes such as trauma, bleeding, and overwhelming infection. The early benefits of this resuscitation are well-established. However, later consequences are less well-understood– in particular, how the inadvertent side effects of administration of a large volume of fluid might alter patient outcomes. There is some evidence from small observational and clinical studies that accumulation of fluid is associated with worse outcome.
We propose to conduct a mutli-centre observational study involving sites in Canada and the UK to obtain a clear picture of what fluid is given and why it is given, as well as other factors involved in fluid accumulation is required. Alongside this, data on the association of fluid balance with requirements for organ support in ICU (such as assisted breathing or kidney dialysis), length of ICU and hospital stay, ICU and hospital outcome, and prevalence of injury to the kidneys will help us to build our hypotheses on how and why fluid accumulation may be harmful and assist with the design of future interventional studies.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
13/SC/0510
Date of REC Opinion
7 Oct 2013
REC opinion
Further Information Favourable Opinion