QUANTUM Research Tissue Bank
Research type
Research Tissue Bank
IRAS ID
228721
Contact name
Freddie Hamdy
Contact email
Research summary
QUANTUM: QUAlity Biobanking INvesTigating Urological Malignancies
REC name
North of Scotland Research Ethics Committee 2
REC reference
22/NS/0004
Date of REC Opinion
15 Feb 2022
REC opinion
Further Information Favourable Opinion
Data collection arrangements
QUANTUM may accept a wide range of samples and data obtained from patients in Oxford, elsewhere in the UK and internationally (including countries outside the EEA):
1. Sample types: different types of samples may be collected under different modules.
a. Tissue from diagnostic investigations and surgical therapies
b. Fresh blood and blood derivatives
c. Part processed samples (e.g. sections for extraction of DNA & RNA).
d. Constructed tissue micro-arrays (TMAs)
e. Historical samples from ProMPT Study (MREC/01/4/061)where consent for future research was given
f. Sample collections from completed studies where consent for future research was given.
g. Tissue from other Biobanks where appropriate consent was given.Collected tissue and blood will be transported at ambient temperature and processed according to tissue banking protocol in the Biobanking laboratory. Processed fresh samples will be stored in HTA compliant freezers at -80C or in liquid nitrogen (for long term storage).
2. Medical and pathological data for linkage to research samples.
In addition to documentation related to patients providing informed consent, QUANTUM also requires that Registration Source and Annual Follow-up Source documents are completed. This will contain demographic and clinical information which will be entered by Tissue Collection Centre research staff into the QUANTUM Clinical Database. As clinical laboratory results become available (e.g. tissue biopsy report etc.), these need to be recorded in the relevant module-specific Tissue Biopsy Source documents. Data will also need to be transferred to the QUANTUM Clinical Database as it would provide important information regarding the diagnosis of the patient.
Research programme
The Biobank collects tissue samples to study the common and specific changes that are required to cause urological cancers of different types. We would make these samples available to the research and clinical community with the aim of improve use of existing treatments and to develop new treatments for these conditions, subject to peer review and approval by the QUANTUM Governance Committee.
Storage license
12217
RTBTitle
QUANTUM: QUAlity Biobanking INvesTigating Urological Malignancies
Establishment organisation
University of Oxford
Establishment organisation address
Churchill Hospital
Old Road, Headington
Oxford
OX3 7LE