Quantitative MRI in Osteoarthritis
Research type
Research Study
Full title
Osteoarthritis: Quantitative Evaluation of Whole Joint Disease with MRI.
IRAS ID
320188
Contact name
Becky Ward
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Knee osteoarthritis is a common disease resulting in pain and stiffness, affecting 1 in 5 adults in England over 45 years of age. Development of new therapies for osteoarthritis is hampered by a lack of imaging tests that respond to changes in disease status. Hence, there is a tremendous need for imaging methods that can non-invasively and quantitatively evaluate the early and reversible change in osteoarthritis.
The recent FDA- and CE-approved clinical knee 7T MRI has the potential to add sensitivity and specificity to advanced MRI biomarkers of osteoarthritis progression. Hence, the study’s primary goal is a more sensitive and higher resolution osteoarthritis assessment using 7T MRI that enables better understanding of the disease’s natural progression and guide/evaluate earlier, personalized treatments.
Additionally, the 3D high-resolution methods already developed at 3T using healthy volunteers show considerable promise for clinical knee MRI – further work will enable faster and higher value knee MRI compared with routine clinical methods.
This study is funded by the U.S. National Institutes of Health. Healthy and early knee osteoarthritis patients will be recruited for this study. The volunteers can decide whether they would like to be scanned at the Clinical Imaging Facility at Hammersmith Hospital and/or the LoCUS 7T MRI Unit owned by King’s College London at St Thomas’ Hospital. Healthy volunteers will attend one scanning session post-enrolment at the site(s) of their choice. Osteoarthritis patients will attend 4 scanning sessions at the site(s) of their choice stretched out over 2 years. Each scanning session will last for up to 1.5 hours. The scans will then be transferred using an encrypted hard drive to secure college computers based at Sir Michael Uren Hub at White City Campus.
REC name
North of Scotland Research Ethics Committee 2
REC reference
23/NS/0084
Date of REC Opinion
28 Aug 2023
REC opinion
Further Information Favourable Opinion