Quantitative MRI in children with juvenile idiopathic arthritis
Research type
Research Study
Full title
Quantifying the utility, feasibility and acceptability of accelerated quantitative MRI in children with juvenile idiopathic arthritis to measure suppression of intra-articular inflammation.
IRAS ID
206363
Contact name
Kieren Hollingsworth
Contact email
Sponsor organisation
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 3 months, 17 days
Research summary
1. This project is to demonstrate that a new, faster MRI scan will provide measurements of the volume and inflammation of the lining of the knee joint before and after corticosteroid joint injections in school age children with juvenile idiopathic arthritis (JIA). The injection is the standard NHS care. We will aim to show that the scans are acceptable to children, parents/carers and clinicians.
2. Present management of JIA aims for early, aggressive treatment to prevent long-term joint damage, but clinicians lack a practical, readily available ‘gold standard’ measure of disease activity to assess response to treatment; instead they rely on multiple indirect clinical and blood tests which do not directly reflect the state of the inflamed knee joint.
3. MRI has great potential as a way of measuring inflammation in JIA, the MRI used in present paediatric practice is not sufficiently sensitive.REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
16/NE/0299
Date of REC Opinion
23 Nov 2016
REC opinion
Further Information Favourable Opinion