Quantitative IgG Ab measurement following COVID-19 vaccination [COVID-19]
Research type
Research Study
Full title
Measurement of COVID-19 antibody concentrations following vaccination of NHS staff against COVID-19.
IRAS ID
292799
Contact name
Garry John
Contact email
Sponsor organisation
Norfolk and Norwich University Hospital
Duration of Study in the UK
1 years, 6 months, 17 days
Research summary
NHS staff working in Norfolk and Norwich University Hospital will be vaccinated against COVID-19 as part of the National vaccination program. This will involve two injections three weeks apart. There will be no additional intervention apart from blood collection.
The Department of Clinical Biochemistry is working with a major test manufacturer to develop and evaluate a quantitative test for Covid-19 antibodies. The NNUH laboratory is the only one in the country to have this test and a study is already underway to check the sensitivity and specificity of the method. The quantitative test will be able to detect not just the presence or absence of antibodies in a person’s blood, to see if they have been exposed to Covid-19, but will be able to measure how much of an immune response the person has had. This is important for understanding how people are reacting to the vaccine for Covid-19.
We will use this method to measure the concentration of COVID-19 antibodies in NHS staff following vaccination for COVID-19.A 6mL blood sample (one teaspoon full) for COVID-19 antibody measurement will be collected before the first injection, then weekly until the second injection. Blood samples will then be collected at one week then monthly for 18 months or until the COVID-19 antibodies are undetectable.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
20/NE/0287
Date of REC Opinion
22 Dec 2020
REC opinion
Favourable Opinion