Quality of life&depression in Chronic kidney disease
Research type
Research Study
Full title
Quality of life&depression in Chronic kidney disease stage4(as controls) compared with Chronic kidney disease patients on renal replacement therapy.
IRAS ID
157920
Contact name
WONG C
Contact email
Sponsor organisation
University Hospital Aintree NHS Trust
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
When evaluating and improving health care in chronic diseases, symptoms, function in daily life and well-being are important patient outcomes . Health-related quality of life (HRQoL) is a significant key indicator of how a condition affects the patient’s life. HRQoL assessments can therefore identify possible problem areas related to health experiences. The concept of HRQoL builds on WHO’s definition of health and has been defined as the subjective assessment of the impact of disease and its treatment across the physical, psychological and social domains of functioning and well-being. It is characterized by being multidimensional (reflecting at minimum physiological, psychological and sociological aspects), temporal and subjective.
Chronic kidney disease (CKD) is defined as the presence of kidney damage or a glomerular filtration rate (GFR) < 60 ml/min/1.73 m² for ≥ 3 months , with a prevalence of approximately 10% of the adult population. Stages of CKD depend on the levels of renal function , the higher the CKD stage, the more severe the renal insufficiency. Most CKD tend to progress, and with declined kidney function multiple disorders gradually develop, such as anemia, hypertension, inflammation (i.e. chronic activation of the immune system), malnutrition metabolic and mineral-bone disorders . CKD 1–3 are not usually considered to impact on the individual’s health experience, although some disturbances may already have emerged. However, in CKD 4 the individual perceives an increasing amount of symptoms which may affect the HRQoL . Fatigue, muscle weakness, restless legs, cramps, itching, nausea and loss of appetite are frequently reported symptoms. Conditions like malnutrition, anemia, cognitive dysfunction, sleep disorders, depression, reduced reduced social interaction, physical and sexual functioning and co-morbidities like diabetes and cardiovascular disease (CVD) also impair HRQoL in CKD patients . Impaired HRQoL is well described among patients on dialysis treatment . Low HRQoL scores in dialysis patients are further strong and independent predictors of hospitalization and mortality . However, some studies have demonstrated deteriorated HRQoL also in early stages of CKD, especially in physical health but also in mental health . When following patients in CKD 3–5 up to four years, it was shown that HRQoL deteriorated over time, especially in those with a history of congestive heart failure .
Aim
•To assess the Quality of life and depression in End stage renal patients(CKD5) on renal replacement therapy•To compare the findings with chronic kidney disease patients without renal replacement therapy(CKD4/5)
Background to the study
1)Frequent Hospitalisation
2)Link between mortality and quality of life in Chronic kidney disease patients
3)Longer duration of hospital stay may be related to quality of life and depression
The health-related quality of life (HRQOL) of patients with chronic kidney disease influences the timing of the initiation of dialysis, whether they continue to work with progressive kidney failure and whether they maintain an active role in the home and community
REC name
London - Surrey Research Ethics Committee
REC reference
15/LO/0858
Date of REC Opinion
11 Aug 2015
REC opinion
Further Information Favourable Opinion