Quality of Life after Cytoreductive Surgery and HIPEC for Pseudomyxoma

• Research type

  Research Study

• Full title

  Long-term Quality of Life after Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei

• IRAS ID

  208899

• Contact name

  Adam Stearns

• Contact email

  surgical.research@christie.nhs.uk

• Sponsor organisation

  The Christie Hospital NHS Foundation Trust

• Duration of Study in the UK

  0 years, 6 months, 0 days

• Research summary

  Pseudomyxoma peritonei (PMP) is a rare condition usually caused by an appendix tumour bursting. There is a gradual build-up of large volume of jelly within the abdomen. Although it is not characterised by distant spread as with normal cancers, untreated it is characterised by inevitable disease progression with a reported 10-year survival rate of 30%.
  Over the last 20 years, aggressive surgical treatment for this has been developed, termed cytoreductive surgery, which aims to strip out all visible disease where possible. This is then followed by a heated bath of chemotherapy (chemical) agents placed directly in the abdominal cavity during the operation (heated intraperitoneal chemotherapy, HIPEC) to kill any remaining tumour cells.

  Although understanding long-term quality of life outcome is essential in cancer practice, currently there is little published literature on quality of life outcomes after treatment for PMP. The Christie NHS Foundation Trust is in a unique situation in that it is one of two centres in the UK that are nationally commissioned for treatment of PMP, and thus has among the largest case-series of PMP anywhere worldwide.

  Patients treated with cytoreductive surgery and HIPEC between January 2003 and December 2011 were offered standard quality of life questionnaires at clinic appointments as part of routine clinical care before and after surgery. The aim for this study is to provide a single snap-shot ("cross-sectional") assessment of all surviving patients, providing up to 13 years follow-up for these patients. Currently there are no such long-term data reported. As we already have data from before and after surgery for many of these patients, this will provide an insight into how the quality of life changes with time after such major surgery.

• REC name

  East Midlands - Leicester Central Research Ethics Committee

• REC reference

  16/EM/0297

• Date of REC Opinion

  1 Jul 2016

• REC opinion

  Favourable Opinion