qSOFA, SIRS, and NEWS for predicting mortality in sepsis
Research type
Research Study
Full title
qSOFA, SIRS, and NEWS for predicting mortality in sepsis patients in the Emergency Department
IRAS ID
227046
Contact name
E F Nsutebu
Contact email
Sponsor organisation
Royal Liverpool Hospital
Duration of Study in the UK
0 years, 3 months, 31 days
Research summary
Identifying patients with suspected infection who have sepsis and are at high risk of adverse outcomes is vital to allow early, effective interventions. The definition and clinical criteria for sepsis were updated in 2016, and included a new screening tool – the quick Sequential Organ Failure Assessment (qSOFA) – for detecting sepsis and its complications. Sepsis was previously identified and defined using the Systemic Inflammatory Response Syndrome (SIRS), which had come under scrutiny for its poor specificity. Meanwhile, the National Early Warning Score (NEWS) has been widely adopted in the UK NHS in recent years as a tool to assess and monitor the clinical condition of all hospital patients. This study seeks to evaluate the prognostic accuracy of these 3 scoring systems for predicting adverse outcomes – mortality, intensive care unit (ICU) admission, and ICU length of stay – in patients admitted with suspected sepsis via the emergency department of the Royal Liverpool Hospital.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
17/NE/0140
Date of REC Opinion
26 Apr 2017
REC opinion
Favourable Opinion