QIST Collaborative – Arthroplasty Research Cohort (ARC) Study
Research type
Research Study
Full title
A collaborative, longitudinal observational cohort study of patients undergoing primary hip and knee replacements in the United Kingdom
IRAS ID
310843
Contact name
Mike Reed
Contact email
Sponsor organisation
Northumbria Healthcare NHS Foundation Trust
Duration of Study in the UK
8 years, 0 months, 0 days
Research summary
Although overall patient satisfaction is high in patients undergoing hip and knee replacements, up to 20% of patients remain dissatisfied. We have designed a national observational cohort study to investigate patient reported and clinical outcomes. Building on lessons from COVID 19, patients are recruited and consented online, and all data collection is electronic.
Patients will be invited to participate by collaborating surgical teams nationally in outpatient clinics at the time of being added to a waiting list, in addition to an advertising campaign to recruit patients. They will be directed to an online portal where they will be able to review further information.
Consent and data collection is completed electronically through patients entering data online. Baseline demographics and characteristics are recorded, including details of socio-demographics, lifestyle, health status and patient reported outcome measures (PROMs). Patients then undergo hip/knee replacement and postoperative rehabilitation according to the standard care and protocols of the hospital and the preferences of their treating surgeon.
Follow-up data, including PROMs, will be collected via online questionnaires up to two years following surgery. A key component of the cohort study is data linkage to routinely collected health data including the National Joint Registry, Hospital Episode Statistics and mortality data. The study will ultimately also provide an invaluable resource and infrastructure which will enable us to embed multiple trials within the cohort study, using a ‘Trials within Cohorts’ (TwiCs) methodology to investigate interventions to improve patient outcomes.
This design, using remote recruitment and electronic data collection, will place little burden upon patients and requires no additional service contact. This also makes research highly efficient and cost effective. A similar model has been demonstrated effectively already in the COVIDENCE UK cohort study, and CORONAVIT trials successfully recruiting patients and collecting data electronically.
REC name
HSC REC A
REC reference
22/NI/0135
Date of REC Opinion
6 Sep 2022
REC opinion
Further Information Favourable Opinion