Pulmonary vein Reconnection following Ablation Index-guided ablation
Research type
Research Study
Full title
Pulmonary vein Reconnection following Ablation Index-guided ablation: a Success Evaluation (PRAISE)
IRAS ID
193216
Contact name
Dhiraj Gupta
Contact email
Sponsor organisation
Liverpool Heart & Chest Hospital
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Atrial fibrillation (AF) is the commonest condition affecting the rhythm of the heart. Tablets to try to normalise the heart rhythm rarely work well. As a result, doctors have devised a treatment called catheter ablation in which special wires are used to deliver heat energy (called ablation lesions) on the inside surface of the heart to destroy or isolate the abnormal sources of electrical impulses that may be driving AF. Unfortunately, in many patients (more than 1 in 2), some of these ablation lesions heal, and that healing is undesirable as it leads to AF recurrence. Many of these patients then need a second procedure to deliver further ablation at these recovered areas. \nRecent research has shown that monitoring of heat delivery with a factor called Ablation Index may be useful in predicting which ablation lesions are less likely to recover. Therefore, we aim to carry out AF ablation guided with Ablation Index and observe whether this will be associated with better durability of ablation lesions, and thereby better freedom from AF.\nThis study will include patients with persistent AF, those whose AF episode(s) last for longer than seven days. All patients participating in the study will undergo an initial ablation treatment guided by ablation Index (AI). All patients will undergo a repeat procedure 8-10 weeks after their initial treatment. Any gaps found during the second procedure will be closed again by delivery of ablation. \nAll participants will be issued with a simple to use handheld heart rhythm monitor, and asked to make a 30 second recording of their heart rhythm each day, and also whenever they have symptoms. The monitor stores these recordings and they will be downloaded at review appointments arranged 6 weeks, 3 months, 6 months and 12 months after the initial ablation procedure.\n\n\n\n
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
15/NW/0930
Date of REC Opinion
4 Jan 2016
REC opinion
Further Information Favourable Opinion