Psoriasis DiseAse Research 1.0
Research type
Research Study
Full title
Longitudinal study of the Psoriatic Disease Continuum
IRAS ID
188955
Contact name
Philip Laws
Contact email
Sponsor organisation
Medicine and Health Research Governance
Duration of Study in the UK
5 years, 0 months, 2 days
Research summary
Psoriasis is a chronic immune mediated disease of the skin which affects approximately 1% of the population. It is increasingly clear that psoriasis represents a group of overlapping disease and that this may have an impact on a number of factors including complications of disease and response to treatment. Psoriatic arthritis is an inflammatory disease of the joints seen in association with psoriasis and may have a profound affect on ability to perform activities of normal daily life. Other disease associations include cardiovascular disease, metabolic syndrome (including obesity, diabetes and hypertension) and depression. The relationship between psoriasis and these other diseases is complicated by factors including adverse lifestyle choices more frequently seen in psoriasis patients compared to the background population.
Identifying factors that may be predictive of comorbid disease will afford an opportunity to focus treatment and preventive strategies in a more effective manner. This study will recruit patients from dermatology and rheumatology clinics within Leeds Teaching Hospitals Trust and will follow them up over a 5-year period. These patients will have standard data recorded and entered into a hospital database. There will be 3 additional sub studies within this larger group of patients providing additional insights into; biological sub study, cutaneous biology sub study and musculoskeletal sub study. The biological sub study will involve a series of biological samples (blood, urine) samples to be taken over the course of the study. The cutaneous biology sub study will involve a skin biopsy, tape stripping (adhesive tape applied and removed from the surface of the skin), mouth swab and culture of bacterial organisms from the skin. The musculoskeletal sub study will involve an ultrasound of the joint (power Doppler) and imaging of blood vessels in the nails and skin (optical coherence tomography and nail fold capillaroscopy). This will provide novel insights into patterns of disease, response to treatment and identifying risk factors for associated disease.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
16/YH/0086
Date of REC Opinion
16 May 2016
REC opinion
Further Information Favourable Opinion