PS-measure
Research type
Research Study
Full title
Psoas muscle area and density as preoperative measures of sarcopenia and predictors of surgical outcomes in major colorectal cancer surgery.
IRAS ID
281127
Contact name
Andreia F Rodrigues Batista
Contact email
Sponsor organisation
York Teaching Hospital NHS Foundation Trust
Duration of Study in the UK
0 years, 3 months, 28 days
Research summary
Population ageing and improvement of surgical and anaesthetic techniques have caused a significant rise in the mean age of patients undergoing surgery for colorectal cancer. Careful preoperative evaluation is important to identify those patients at higher risk of complications and mortality. It allows better optimization before surgery or consideration of alternative therapies, improving patient information and expectations.
Age and comorbidities can be used to estimate surgical outcomes. Recently, several studies have shown that frailty is a better discriminator of risk and can provide added value to the preoperative assessment. There is, however, no standard to evaluate frailty and most scales are extensive, cumbersome to undertake and subjective.
Frailty is a complex geriatric syndrome characterized by progressive loss of functional reserve. One of its characteristics is weakness, which is why several studies have tried to quantify frailty through muscle mass. Muscle measurements have shown promise in preoperative evaluation of surgical outcomes across different procedures, even minor ones. The psoas muscle is the most commonly used in the literature given its important function in maintaining posture.
The main objective of this study is to determine whether psoas muscle measurements are significant predictors of postoperative outcomes.
This will be a retrospective analysis of prospectively collected data from a cohort of patients who underwent preoperative assessment for major colorectal cancer excision at York Hospital from 2015.
We will measure the psoas muscle in preoperative CT scans of patients who underwent cardiopulmonary exercise testing at York Hospital before colorectal surgery. We will then compare how psoas muscle measurements compare to other commonly used predictors in predicting postoperative outcomes.REC name
N/A
REC reference
N/A