PROXIMO - PRolonged Overnight oXIMetry for Obstructive sleep apneoa
Research type
Research Study
Full title
PROXIMO: A cohort study to investigate the incidence of obstructive sleep apnoea using prolonged overnight oximetry in an unselected population referred to secondary care reporting excessive daytime sleepiness.
IRAS ID
254464
Contact name
Justin Pepperell
Contact email
Sponsor organisation
Taunton and Somerset NHS Foundation Trust
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
EudraCT, 2018-004375-12
Duration of Study in the UK
1 years, 6 months, 27 days
Research summary
Screening for patients with obstructive sleep apnoea is usually limited to a single night home recording or inpatient sleep study. There is however significant night to night variability in the presence and severity of obstructive sleep apnoea. Screening patients with a single night recording may fail to identify patients with significant disease, conversely they may be offered therapy with a machine that blows in air to splint open the airway (continuous positive airway pressure - CPAP), based on an unrepresentative night. It is believed that particularly patients with mild or moderate disease may show the largest night to night variability and their disease may be missed.
Patients referred for assessment at a district general hospital sleep centre will undergo the current standard single night recording using a wristwatch oximeter (PulsOxi3000). In addition they will also be asked to undertake 4 nights recording using a device capable of prolong recordings (CheckMe O2 wrist pulse oximeter).After completing the oximetry recording patients will return to the standard clinical care pathway. Patients meeting the current threshold to be offered a trial of CPAP treatment from a single night recording or on one or more nights prolonged recording will also be offered a CPAP trial.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
20/LO/0055
Date of REC Opinion
14 Feb 2020
REC opinion
Further Information Favourable Opinion