Proteomic analysis of myeloproliferative neoplasms and leukaemias
Research type
Research Study
Full title
The use of mass spectrometry to identify novel regulators of myeloproliferative neoplasms and leukaemias and their exploitation in identifying novel treatments strategies.
IRAS ID
142668
Contact name
A.D. Whetton
Contact email
Sponsor organisation
University of Manchester
Research summary
Blood progenitor cells obtained from patients suffering from a variety of leukaemias, will be analysed using the latest protein analysis techniques and compared to samples from people not suffering from the disease. This analysis will allow the identification of novel and important regulators of leukaemeogenesis which we will exploit in the generation of novel treatment strategies. It will also allow us to build on the mass of data obtained from cell line models of the diseases, we identified a number of protein and phosphosites that were involved in the activity of the oncogenes in the diseases. Thus these samples will allow us to validate the cell line data in patient material, as well as confirm the proteins identified as possible drug targets. The blood progenitor cells will also be used in the assessment of these treatment strategies in further biological analyses such as growth and differentiation assessment.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
14/LO/0489
Date of REC Opinion
18 Mar 2014
REC opinion
Favourable Opinion