Protein Turnover in Renal Failure
Research type
Research Study
Full title
Protein Turnover and Resting Energy Expenditure in Renal Failure
IRAS ID
108969
Contact name
Sivakumar Sridharan
Contact email
Research summary
Kidneys play a major role in protein and amino acid metabolism. Hence, in renal failure, disturbed protein metabolism may be expected. It has been shown that kidney failure is associated with impairment of various amino acid metabolisms. Moreover, malnutrition is a common finding in patients with kidney disease and nutritional indices worsen with progression of kidney disease. Protein and energy malnutrition in patients with advanced kidney disease lead to increased mortality. A better understanding of whole body protein metabolism in renal failure is essential for the nutritional management of these patients. In 12 patients with kidney disease (6 on haemodialysis and 6 with advanced kidney disease not on dialysis), we will measure whole body protein turnover and resting energy expenditure. Protein turnover is measured by continuous infusion of stable, non-radioactive isotope labelled leucine for around 3 hours and calculating protein turnover through isotope enrichment in blood samples. Resting energy expenditure will be measured using indirect calorimeter.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
13/EE/0158
Date of REC Opinion
27 Jun 2013
REC opinion
Further Information Favourable Opinion