Protein Targets and Calcium Signalling in Colorectal Liver Metastases
Research type
Research Study
Full title
Protein Targets and Calcium Signalling Pathways as Targets for the Treatment of Colorectal Liver Metastases
IRAS ID
152366
Contact name
Peter Webster
Contact email
Research summary
Bowel cancer that has spread to the liver has limited treatment options. Only around 20% of people with the disease are suitable for surgery. The remaining 80% of patients may have chemotherapy, which is not curative, living on average for only 21 months. New treatment modalities are urgently needed.
The ability of this cancer to develop its own blood supply is crucial to its spread and survival. Over the last few years we have been investigating the role of calcium signalling in the cells that line the tumour blood vessels (endothelial cells), in human patients, under ethical approval granted in 2010. This work has yielded novel data regarding variation of protein expression between normal healthy endothelial cells and liver tumour endothelial cells. It is our intention to explore this further, using samples from patients undergoing curative liver tumour resection. We will further characterise the role of calcium signaling in this disease and plan to target the overexpressed tumour endothelial cell proteins to develop new treatments.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
14/YH/1001
Date of REC Opinion
30 May 2014
REC opinion
Favourable Opinion