PROTECT-ASUC [COVID-19]
Research type
Research Study
Full title
PROTECT-ASUC: Covid-19 Pandemic response of assessment, endoscopy and treatment in Acute Severe Ulcerative Colitis. A multi center observational observational case-control study.
IRAS ID
284030
Contact name
Shaji Sebastian
Contact email
Sponsor organisation
Hull University Teaching Hospital NHS Trust
Duration of Study in the UK
0 years, 3 months, 0 days
Research summary
Ulcerative colitis (UC) causes inflammation on the inner lining of the colon (The large bowel). Sometimes, the condition can become so severe that a hospital admission is required (Acute Severe Ulcertaive Colitis-ASUC). ASUC can be a life threatening condition for which specific treatment plans within the hospital setting are required. Unfortunately these treatment plans are largely ill-defined with approximately 30-40% of patients admitted with ASUC requiring emergency surgery to remove the large bowel (colectomy). Colonoscopy (a small camera placed into the bowel) and various tests are used to assess the severity of the problem but these are not fully accurate in predicting risk and hence treatment can be very variable between clinicians and hospitals. This variability in practice can potentially impact on patient outcomes.\n\nIntravenous corticosteriods is the mainstay of management but approximately 40% of patients will not respond to the steroids. If steroids are not improving the condition then alternative treatments can be given such as infliximab or cyclosporine and failing these emergency colectomy, which is an additional risk. \n\nThe management of ASUC during the coronavirus pandemic poses several additional challenges to both the patient with ASUC and clinical team with a potentially higher threshold to admit patients who have ulcerative colitis and coronavirus, availability of core services such as endoscopy and surgical facilities.\n\nThis study will collect retrospective data of routine NHS care from case records of a cohort of patients with ASUC across the UK to determine the impact any changes and adaptations to management of ASUC during coronavirus pandemic on the management and clinical outcomes in patients hospitalized with ASUC.
REC name
N/A
REC reference
N/A