PROPANE STUDY
Research type
Research Study
Full title
PROPANE STUDY: Probing the Role of Sodium Channels in Painful Neuropathies
IRAS ID
143141
Contact name
Rayaz A Malik
Contact email
Sponsor organisation
The University of Manchester
Research summary
Approximately 20% of diabetic patients develop ’painful diabetic neuropathy’ which is characterised by sharp lancinating and hot burning pains in the feet. At present we do not understand why patients develop these pains. However, we do know that there is altered expression of certain channels (sodium channels) on the nerve endings in other painful neuropathies due to genetic defects.
The “PROPANE STUDY“ aims to address these issues through a solid clinical and genetic approach employing an innovative technological platform to resolve the genetic architecture of painful diabetic neuropathy. We will undertake a targeted sequencing approach to look at 5 sodium channel genes (unbiased whole exome sequencing and transcriptome assay). Identification of specific genetic abnormalities in a proportion of these patients will allow us to stratify these patients and treat them using more specific treatments which alter sodium channel activity.REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
14/NW/0093
Date of REC Opinion
5 Mar 2014
REC opinion
Further Information Favourable Opinion