PROMINENT Smoking Cessation Study
Research type
Research Study
Full title
Discovering the molecular signatures of cancer PROMotion to INform prevENTion (PROMINENT): Smoking Cessation Study
IRAS ID
330336
Contact name
Philip Crosbie
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
2 years, 2 months, 28 days
Research summary
Tobacco smoking is known to increase the risk of cancer in both humans and mouse models. The causal link between smoking and tumours of the lung, and up to 14 other cancer types, has been well established. While there is compelling epidemiological evidence to link tobacco smoking with cancer risk, the underlying biological mechanisms are not well understood. Importantly, we do not understand how smoking impacts cells in the body over time and how it promotes cancer development.
To determine the specific role of tobacco smoking in tumour promotion, this study will aim to investigate the effect of changes in smoking on tissue biology. We will collect serial samples of mouth and nose tissues, blood samples (optional) and breath carbon monoxide measurements from volunteers undergoing a smoking cessation lifestyle modification programme. We hope that by comparing samples obtained prior to the intervention and at subsequent time points thereafter, we will be able to observe differences in the molecular and clonal architecture of normal tissues. These changes will help us understand the mechanisms by which smoking promotes cancer development and could help identify molecular targets for prevention. Within this study, we also aim to assess the impact of smoking cessation on normal cells in those who go on to use e-cigarettes versus those who use other means.
This is an observational study. Current cigarette smokers, with no previous history of cancer, who attend the Greater Manchester Lung Health Check Programme and / or Manchester CURE (Stop Smoking) Project will be approached and asked if they wish to take part in the study. Study visits will take place on mobile trucks in the community, Manchester University NHS Foundation Trust hospital sites or the participant’s home. The maximum duration of time spent by each participant in the study will be 12 months.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
24/EE/0071
Date of REC Opinion
5 Jun 2024
REC opinion
Further Information Favourable Opinion